Paper

Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells.

Published Dec 1, 2008 · J. Park, Cheng-yun Jin, Bok-kyu Lee

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

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Abstract

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In Vitro StudyHighly Cited

Study Snapshot

Naringenin, a flavonoid found in citrus fruits, induces apoptosis in human leukemia THP-1 cells through caspase-3 activation and mitochondria dysfunction, suggesting its potential as a therapeutic agent for leukemia prevention.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells.

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