Paper

N-Desmethylclozapine, a Major Clozapine Metabolite, Acts as a Selective and Efficacious δ-Opioid Agonist at Recombinant and Native Receptors

Published Apr 1, 2007 · P. Onali, M. Olianas

Neuropsychopharmacology

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Abstract

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In Vitro StudyRigorous Journal

Study Snapshot

N-desmethylclozapine (NDMC) acts as a selective and efficacious -opioid receptor agonist, potentially contributing to the clinical actions of the atypical antipsychotic clozapine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

N-Desmethylclozapine, a Major Clozapine Metabolite, Acts as a Selective and Efficacious δ-Opioid Agonist at Recombinant and Native Receptors

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