Paper
N-Functionalised polyfluoropyridazin-3(2H)-one derivatives
Published Oct 24, 2009 · G. Pattison, G. Sandford, D. Yufit
Tetrahedron
Q3 SJR score
12
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
This study presents a novel approach for synthesizing polyfunctional pyridazinone systems using sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Citations
Effects of Replacing Oxygenated Functionality with Fluorine on Lipophilicity.
Replacing oxygenated functionality with fluorine significantly reduces lipophilicity, with electron-donating groups on aromatic rings increasing the difference and electron-withdrawing groups leading to smaller differences.
2021·32citations·R. Glyn et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
The Effects on Lipophilicity of Replacing Oxygenated Functionality with Their Fluorinated Bioisosteres
Replacing oxygenated functionality with fluorine atoms in medicinal chemistry generally increases the difference in lipophilicity between oxygenated compounds and their fluorinated analogues.
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Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative
Schiff base metal complexes synthesized from aniline derivatives show greater antioxidant activity than the ligand itself, with potential applications in antimicrobial and antifungal treatments.
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19F and 13C GIAO-NMR computations are powerful tools for structurally identifying polyfunctional, polycyclic perfluoroheteroaromatic compounds and aiding NMR resonance assignment.
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Journal of Fluorine Chemistry