Paper
Niacinamide: A B vitamin that improves aging facial skin appearance.
Published Mar 21, 2006 · J. Oblong, D. Bissett, C. Berge
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
162
Citations
2
Influential Citations
Abstract
BACKGROUND In multiple chronic clinical studies, topical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging facial skin (eg, reduction in the appearance of hyperpigmentated spots and red blotchiness). OBJECTIVE To clinically determine the effect of topical niacinamide on additional skin appearance and property end points (wrinkles, yellowing, and elasticity). METHODS Female white subjects (N = 50) with clinical signs of facial photoaging (fine lines and wrinkles, poor texture, and hyperpigmented spots) applied 5% niacinamide to half of the face and its vehicle control to the other half twice daily for 12 weeks (double blind, left-right randomized). Facial images and instrumental measures were obtained at baseline and at 4-week intervals. RESULTS Analyses of the data revealed a variety of significant skin appearance improvement effects for topical niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing). In addition, elasticity (as measured via cutometry) was improved. Corresponding mechanistic information is presented. CONCLUSION In addition to previously observed benefits for topical niacinamide, additional effects were identified (improved appearance of skin wrinkles and yellowing and improved elasticity).
RCT
Highly CitedTopical niacinamide improves aging facial skin appearance by reducing fine lines, wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and increasing elasticity.
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