Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition.

doi:10.1016/J.EXER.2005.08.006

Paper

Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition.

Published Mar 1, 2006 · N. Uehara, Katsuaki Miki, R. Tsukamoto

Experimental eye research

Q1 SJR score

43

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1

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Nicotinamide protects retinal structure from MNU-induced photoreceptor cell apoptosis in rats by inhibiting both PARP activity and the JNK/AP-1 signaling pathway.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition.

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