Paper
Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
Published Aug 1, 2021 · Harshani Nadeeshani, Jinyao Li, T. Ying
Journal of Advanced Research
Q1 SJR score
105
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Literature Review
Highly CitedStudy Snapshot
Nicotinamide mononucleotide (NMN) shows promise as an anti-aging health product by elevating NAD+ levels in the body, but proper clinical investigations are needed to confirm its effectiveness and safety.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Safety evaluation after acute and sub-chronic oral administration of high purity Nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats.
NMN-C® is safe for short to intermediate term oral administration in rats, with a No-Observable Adverse Effect Level (NOAEL) of ≥ 1500 mg/kg/d.
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Clinical Evidence for Targeting NAD Therapeutically
NAD supplementation shows promising results for treating psoriasis and enhancing skeletal muscle activity, but further trials are needed to determine optimal methods and target conditions.
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Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
Nicotinamide mononucleotide supplementation effectively improves the quality of maternally aged oocytes, enhancing reproductive outcomes for aged women and assisted reproductive technology.
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EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE
Exercise-induced benefits on glucose handling in diet-induced obesity are reduced by concurrent nicotinamide mononucleotide administration, suggesting NMN may not be beneficial when NAD+ levels are replete.
2020·12citations·Joseph G. Yu et al.·bioRxiv
bioRxiv
Citations
Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis.
The PnuC gene plays a crucial role in nicotinamide mononucleotide synthesis, which may have potential applications in treating aging-related diseases and contributing to cellular health maintenance.
2025·0citations·Giang Thi Thu Vo et al.·Biotechnology and applied biochemistry
Biotechnology and applied biochemistry
Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease
Caloric restriction and caloric restriction mimetics show potential in preventing neurodegenerative disorders associated with aging, but more clinical trials are needed for confirmation.
2025·0citations·Anchal Trisal et al.·Neuroscience
Neuroscience
Silk fibroin for cosmetic dermatology
Silk fibroin (SF) enhances skin luster and elasticity, reduces pigmentation, combats skin aging, and promotes scalp care due to its unique moisturizing, anti-inflammatory, and antioxidant properties.
2025·0citations·Songjie Li et al.·Chemical Engineering Journal
Chemical Engineering Journal
β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway
-nicotinamide mononucleotide (NMN) protects granulosa cells from oxidative stress and enhances ovarian responsiveness in sheep, potentially serving as a novel metabolic biomarker for enhancing ovarian function.
2024·0citations·Yu Cai et al.·Antioxidants
Antioxidants
Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier
Nicotinamide mononucleotide-loaded liposomes with ANG peptide significantly improve their ability to cross the blood-brain barrier, potentially benefiting patients with various diseases.
2024·0citations·Tiantian Wang et al.·Applied Sciences
Applied Sciences
Biological production of nicotinamide mononucleotide: a review.
Nicotinamide mononucleotide (NMN) has therapeutic potential against aging-related conditions and is environmentally sustainable when produced using microorganisms as biocatalysts or cell-free systems.
2024·0citations·Rhudith B Cabulong et al.·Critical reviews in biotechnology
Critical reviews in biotechnology
Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions
Lactic acid bacteria show potential for large-scale nicotinamide mononucleotide production through metabolic engineering strategies and future research directions.
2024·0citations·Linghui Kong et al.·Frontiers in Microbiology
Frontiers in Microbiology