2,5-Dimethyl-4-phenylpyridine is nitrated in the para position of the phenyl ring. Further nitration of the resulting nitro compound gives a mixture of isomeric dinitro derivatives. In the case of 4-phenylisocinchomeronic acid the nitro group enters the meta position of the phenyl ring.

Nitration of 2,5-disubstituted 4-phenylpyridine leads to a mixture of isomeric dinitro derivatives, while 4-phenylisocinchomeronic acid has a nitro group enter the meta position of the phenyl ring.

Paper

Nitration of some 2, 5-disubstituted 4-phenylpyridin es

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