Nitrosation of 1-Substituted 3-(2-Pyridylmethyl) ureas and Related Compounds

doi:10.1248/CPB.31.1738

Paper

Nitrosation of 1-Substituted 3-(2-Pyridylmethyl) ureas and Related Compounds

Published May 25, 1983 · S. Kamiya, S. Sueyoshi

Chemical & Pharmaceutical Bulletin

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Abstract

Nitrosation of 1-methyl-(Ia), 1-(2-chloroethyl)-(Ib) and 1-phenyl-3-(2-pyridylmethyl)-urea (Id) with hydrochloric acid and sodium nitrite gave exclusively the corresponding 1-nitrosoureas (IIa, b, d). However, nitrosation of the 1-isopropylurea (Ic) gave a mixture of the 1-nitrosourea (IIc) and the 3-nitrosourea (IIIc). Similar results were also obtained in the nitrosation of 1-substituted 3-(2-pyridylethyl) ureas (Ie-h). The reaction of the nitrosoureas and m-chloroperbenzoic acid in chloroform gave the N-oxides (IVa-f, Vc, f, g), which were more stable than the nitrosoureas.

Study Snapshot

Nitrosation of 1-substituted 3-(2-pyridylmethyl) ureas with hydrochloric acid and sodium nitrite produces 1-nitrosoureas, which are more stable than the nitrosoureas themselves.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Nitrosation of 1-Substituted 3-(2-Pyridylmethyl) ureas and Related Compounds

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References

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Waste-free chemistry of diazonium salts and benign separation of coupling products in solid salt reactions.

Waste-free chemistry of diazonium salts and benign separation of coupling products in solid salt reactions enable efficient syntheses of various compounds without producing waste.