N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.

doi:10.1016/J.BMCL.2004.02.051

Paper

DOI: 10.1016/J.BMCL.2004.02.051

N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.

Published May 3, 2004 · J. Carson, S. Coats, E. Codd

Bioorganic & medicinal chemistry letters

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

N,N-dialkyl-4-(9-aryltropanylidenemethyl)benzamides, 15a and 15c, show high affinity for the delta opioid receptor and excellent selectivity versus the micro opioid receptor, exhibiting antinociceptive activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/S1567-5769(01)00032-7

Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

B2 bradykinin receptors directly coupled to Gq/11 regulate intracellular calcium release in Chinese hamster ovary cells, providing a useful system for studying potential agents affecting B2 receptor function.

2001·18citations·S. -. Zhang et al.·International immunopharmacology

International immunopharmacology

DOI: 10.1021/JM000427G

Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.

Transposition of the internal nitrogen atom in delta-selective agonists can produce high-affinity, fully efficacious compounds, with structural features promoting delta receptor affinity and mu receptor affinity.

2001·14citations·J. B. Thomas et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1021/JM000228X

New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased In vitro metabolic stability.

New diarylmethylpiperazines show improved in vitro binding and metabolic stability, offering potential for improved nonpeptide delta opioid agonists with improved side-effect and abuse liability profiles compared to classical opioids.

2000·89citations·N. Plobeck et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/S0960-894X(00)00209-2

4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.

High affinity and selective ligands for the delta opioid receptor show diminished agonist activity and antagonism compared to piperidine-based compounds like 3.

2000·4citations·James B. Thomas et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/S0960-894X(00)00182-7

Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.

4-diarylaminotropanes show potential as potent and selective delta opioid agonists, with endo isomers being more potent and selective than exo isomers.

2000·6citations·R. E. Boyd et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

Citations

DOI: 10.1007/s11094-020-02247-2

Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors

Two benzamide derivatives (5b, 8b) show significant inhibitory effects on butyrylcholinesterase enzyme, with low toxicity levels.

2020·1citation·M. Abbasi et al.·Pharmaceutical Chemistry Journal

Pharmaceutical Chemistry Journal

DOI: 10.1186/s13065-020-00703-4

Synthesis, molecular docking and molecular dynamic simulation studies of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives as antidiabetic agents

The synthesized compounds show potential as antidiabetic agents, with compound 5o showing the most activity against -glucosidase and -amylase, and having negligible toxicity, good solubility, and absorption profile.

2020·9citations·Samridhi Thakral et al.·BMC Chemistry

BMC Chemistry

DOI: 10.4172/2329-6798.1000194

Pharmacological Potential of Benzamide Analogues and their Uses in Medicinal Chemistry

Benzamide analogues possess various pharmacological activities, making them a promising target for developing new and more effective pharmaceuticals.

2016·36citations·M. Asif·Modern Chemistry & Applications

Modern Chemistry & Applications

DOI: 10.1002/tcr.201600103

Chiral Bidentate NHC Ligands Based on the 1,1'-Binaphthyl Scaffold: Synthesis and Application in Transition-Metal-Catalyzed Asymmetric Reactions.

Chiral NHC ligands based on the 1,1'-binaphthyl scaffold show high catalytic activities and enantioselectivity for various metal-catalyzed asymmetric reactions.

2016·11citations·Qin Xu et al.·Chemical record

Chemical record

DOI: 10.1134/S1070428016010164

Synthesis of 4′-alkyl-8-azaspiro[bicyclo[3.2.1]octane-3,2′-morpholin]-5′-ones

This study demonstrates a facile method for synthesis of 4′-alkyl-8-azaspiro[bicyclo[3.2.1]octane-3,2′-morpholin]-5′-one hydrochlorides, which show potential as a novel anti-inflammatory agent.

2016·1citation·A. Mandzhulo et al.·Russian Journal of Organic Chemistry

Russian Journal of Organic Chemistry