N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.

doi:10.1016/j.bcp.2011.10.015

Paper

N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.

Published Jan 15, 2012 · C. Wasowski, Luciana Gavernet, I. Barrios

Biochemical pharmacology

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Abstract

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Non-RCT

Animal Study

Study Snapshot

N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide show potential as anxiolytic and anticonvulsant sulfamides for treating anxiety in individuals with epilepsy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.

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References

Citations

A preclinical study of Elettaria cardamomum for its antianxiety activity in Wistar albino rats

Elettaria cardamomum (cardamom) has anxiolytic and sedative effects, similar to benzodiazepine, in Wistar albino rats, supporting its traditional use as an antianxiety agent.

Polymorphism and thermal behavior of sodium cyclamate

Sodium cyclamate, a common additive in tabletop sweeteners, exhibits thermal stability and polymorphism, with potential for thermal degradation to N,N-diciclohexyl sulfamide, a potential anxiolytic compound.

Anxiolytic Effects of the Methanolic Extract of Bacopa monniera in Mice

The methanolic extract of Bacopa monniera (MEBM) demonstrates strong and dose-dependent anxiolytic effects in animal models of anxiety, supporting its traditional use as a potent agent to combat anxiety.

Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides

This study developed a facile and efficient method for synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides, providing a valuable approach for medicinal chemistry research.

N‐propyl‐2,2‐diphenyl‐2‐hydroxyacetamide, a novel &agr;‐hydroxyamide with anticonvulsant, anxiolytic and antidepressant‐like effects that inhibits voltage‐gated sodium channels

N-propyl-2,2-diphenyl-2-hydroxyacetamide (compound 5) shows anticonvulsant, anxiolytic, and antidepressant-like effects, likely due to its voltage-gated sodium channel blocking properties.