Novel amide and sulphonamide derivatives of 6-(piperazin-1-yl)phenanthridine as potent Mycobacterium tuberculosis H37Rv inhibitors.

doi:10.1016/j.ejmech.2015.01.013

Paper

DOI: 10.1016/j.ejmech.2015.01.013

Novel amide and sulphonamide derivatives of 6-(piperazin-1-yl)phenanthridine as potent Mycobacterium tuberculosis H37Rv inhibitors.

Published Mar 6, 2015 · Kalaga Mahalakshmi Naidu, H. N. Nagesh, Manjeet Singh

European journal of medicinal chemistry

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Abstract

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In Vitro Study

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Novel 6-(piperazin-1-yl)phenanthridine amide and sulphonamide analogues show potent antimycobacterial activity against Mycobacterium tuberculosis H37Rv, with compounds 6m, 6s, and 7d showing excellent activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Sulfonamide Derivatives as Potent Antituberculosis Agents: A Literature Survey of the Past Decade

Sulfonamide derivatives show potential as potent antituberculosis agents, with diverse biological activities, including analgesics, antitubercular, and antifungal properties.

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Photochemical Decarboxylative Radical Alkylation/Cyclization Reaction to Fused Nitrogen Heterocycles by LiI/PPh3 Catalysis

This study developed a visible-light-induced decarboxylative radical cascade cyclization reaction for preparing phenanthridine derivatives with up to 82% yield, without transition-metal catalysts or chemical oxidants.

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This study demonstrates a direct conversion of 2-arylanilines to various phenanthridinones using DMF as a sole carbonyl source, potentially benefiting bioactive molecules and organic optoelectronic materials.

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Compound 1A, a novel Mtb LeuRS inhibitor, shows promising druggability and pharmacokinetic properties, with potential for future clinical trials.

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Discovery of potent antitubercular agents: Design, synthesis and biological evaluation of 4-(3-(4-substitutedpiperazin-1-yl)-quinoxalin-2-yl)-naphthalen-1-ol analogues.

Compounds 5h, 5n, and 5q show potent antitubercular activity against Mycobacterium tuberculosis H37Rv strain, indicating their suitability for further potential drug development.

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Synthesis and Biological Evaluation of Novel Benzhydrylpiperazine-Coupled Nitrobenzenesulfonamide Hybrids

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