Novel fluoroquinolone derivatives bearing N-thiomide linkage with 6-substituted-2-aminobenzothiazoles: Synthesis and antibacterial evaluation

doi:10.1016/J.ARABJC.2012.11.002

Paper

DOI: 10.1016/J.ARABJC.2012.11.002

Novel fluoroquinolone derivatives bearing N-thiomide linkage with 6-substituted-2-aminobenzothiazoles: Synthesis and antibacterial evaluation

Published Feb 1, 2017 · P. C. Sharma, Ankit Jain, M. Yar

Arabian Journal of Chemistry

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel fluoroquinolone derivatives with 6-substituted-2-aminobenzothiazole substituents show significant antibacterial potential against various bacterial strains.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/J.ARABJC.2011.04.008

Synthesis and antibacterial evaluation of novel analogs of fluoroquinolones annulated with 6-substituted-2-aminobenzothiazoles

New fluoroquinolone derivatives with substituted piperazine rings at C-7 position show high in vitro antibacterial activity, with some showing more potent activities against Gram-positive organisms than ciprofloxacin, norfloxacin, and gatifloxacin.

2015·25citations·P. C. Sharma et al.·Arabian Journal of Chemistry

Arabian Journal of Chemistry

DOI: 10.1002/cmdc.201200210

Design, Synthesis, and in vitro Antibacterial Activity of Fluoroquinolone Derivatives Containing a Chiral 3‐(Alkoxyimino)‐2‐(aminomethyl)azetidine Moiety

Novel fluoroquinolone derivatives with a chiral 3(alkoxyimino)2(aminomethyl)azetidine moiety show better antibacterial activity against Gram-positive bacteria than levofloxacin and gemifloxacin, but less active against Gram-

2012·26citations·Kai Lv et al.·ChemMedChem

ChemMedChem

DOI: 10.2174/092986711797535326

Quinazolinone analogs as potential therapeutic agents.

Quinazolinone analogs show potential as diverse therapeutic agents, offering diverse biological responses, including antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, and antiinflammatory properties.

2011·64citations·P. Sharma et al.·Current medicinal chemistry

Current medicinal chemistry

DOI: 10.2174/092986711796391615

New insights into chemistry and anti-infective potential of triazole scaffold.

Triazole scaffolds show promising anti-infective potential, offering a fruitful matrix for further development as promising and superior anti-infective medicinal agents.

2011·61citations·Rajeev Kharb et al.·Current medicinal chemistry

Current medicinal chemistry

DOI: 10.3109/14756360903524304

Pharmacological significance of triazole scaffold

Triazole nucleus is a key structural component in various medicinal agents, with broad and potent pharmacological activities across various drug categories.

2011·439citations·R. Kharb et al.·Journal of Enzyme Inhibition and Medicinal Chemistry

Journal of Enzyme Inhibition and Medicinal Chemistry

Citations

DOI: 10.1002/cbdv.202401159

Synthesis, Molecular Docking, and Anticancer Screening of Ester-based Thiazole Derivatives.

Compounds 3e, 3b, and 3c show potential as effective inducers of apoptosis in cancer cells, with compound 3e showing the highest activity against breast cancer cells and compound 3b showing growth inhibition in colon cancer cells.

2024·0citations·Mustapha Musa et al.·Chemistry & biodiversity

Chemistry & biodiversity

DOI: 10.1016/j.jinorgbio.2024.112750

Synthesis, structures, and cytotoxicity insights of organotin(IV) complexes with thiazole-appended pincer ligand.

Diphenyltin compound 3 shows the highest anti-proliferative effect and potential for breast cancer treatment, inducing apoptosis through reactive oxygen species generation and nuclear changes.

2024·1citation·T. S. Basu Baul et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

DOI: 10.1111/cbdd.14402

Identification of a 2‐phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells

AchEI A6 shows potential antitumor activity in breast cancer cells by disrupting amino acid metabolism, inhibiting migration, and inducing apoptosis.

2023·1citation·Xiao Shi et al.·Chemical Biology & Drug Design

Chemical Biology & Drug Design

DOI: 10.3390/ph16030467

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAFV600E Inhibitors

Compounds 6b and 7b show promising antiproliferative and apoptotic activity against cancer cells by inhibiting EGFR and BRAFV600E, respectively.

2023·7citations·L. Al-Wahaibi et al.·Pharmaceuticals

Pharmaceuticals

DOI: 10.1016/j.arabjc.2023.104612

Design, synthesis, docking, and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents

New thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents show promising activity against human cancer cell lines, with compounds 3a, 3c, 3f, 3i, and 5b showing potent activity and oral bioavailability.

2023·11citations·A. Aly et al.·Arabian Journal of Chemistry

Arabian Journal of Chemistry