A three step synthesis of 3-aminopyrazine-2-carboxylic acid (1) starting from pyrazine-2,3-dicarboxylic acid (5) is described. Diacid 5 is converted via the anhydride 6 into the ammonium salt of the half acid amide 7 which on Hofmann rearrangement gives the title compound in 55% overall yield.

This novel improved synthesis of 3-aminopyrazine-2-carboxylic acid (1,5) from pyrazine-2,3-dicarboxylic acid (5,6) yields 55% overall yield, making it a promising method for preparing pharmaceuticals.

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A novel improved synthesis of 3-aminopyrazine-2-carboxylic acid

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