Paper

Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.

Published Feb 15, 2017 · Wagdy M. Eldehna, G. H. Al-Ansary, Silvia Bua

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Novel indolin-2-one-based sulfonamides show variable inhibitory activity against human carbonic anhydrase isoforms I, II, IV, and VII, with molecular docking studies providing rationale for inhibition results.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.

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