Paper

Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity.

Published Apr 1, 2017 · T. Huong, D. Dung, Nguyen-Van Huan

Bioorganic chemistry

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Abstract

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In Vitro Study

Study Snapshot

Novel N-hydroxybenzamides incorporating 2-oxoindoline show potent histone deacetylase inhibitory effects and potential anticancer activity, with up to 4-fold more cytotoxic than SAHA.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity.

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