Novel pathway for the metabolism of 6-trans-leukotriene B4 by human polymorphonuclear leukocytes.

doi:10.1016/0006-291X(86)90497-3

Paper

DOI: 10.1016/0006-291X(86)90497-3

Novel pathway for the metabolism of 6-trans-leukotriene B4 by human polymorphonuclear leukocytes.

Published Apr 29, 1986 · W. Powell

Biochemical and biophysical research communications

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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A novel pathway for 6-trans-leukotriene B4 metabolism in human polymorphonuclear leukocytes involves reducing the 6- or 10-double bond, leading to either 5,12,20-trihydroxy-6,8,14-eicosatrienoic acid or 5,12,20-trihydroxy-8,

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/s0021-9258(17)43263-7

Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes.

Human polymorphonuclear leukocytes specifically convert LTB4 to its 20-hydroxy metabolite, potentially playing a role in regulating LTB4 levels in vivo.

1984·206citations·W. Powell·The Journal of biological chemistry

The Journal of biological chemistry

DOI:

A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.

A novel leukotriene, 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraen-1,20-dioic acid, was formed by stimulating human polymorphonuclear leukocytes with formylmethionylleuc

1982·140citations·W. Jubiz et al.·The Journal of biological chemistry

The Journal of biological chemistry

DOI: 10.1016/0014-5793(81)80676-X

Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B4 from human leukocytes

This study identified novel oxidized metabolites of leukotriene B4 in human leukocytes, which show potential biological activity against guinea pig lung strips.

1981·257citations·G. Hansson et al.·FEBS Letters

FEBS Letters

DOI: 10.1016/0014-5793(81)80110-X

Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes

This study reveals novel metabolites formed in human leukocytes, not via the leukotriene pathway, which may have potential therapeutic applications.

1981·146citations·J. Lindgren et al.·FEBS Letters

FEBS Letters

DOI: 10.1016/0161-4630(81)90117-8

Transformation of arachidonic acid in leukocytes. Isolation and structural analysis of a novel dihydroxy derivative.

A novel dihydroxy derivative of arachidonic acid, 5S,12S-dihydroxy-6,8,10,14-icosatetraenoic acid, was identified and isolated in leukocytes, showing less than 1% of the myotropic activity of leukotriene B4.

1981·118citations·P. Borgeat et al.·Prostaglandins and medicine

Prostaglandins and medicine

DOI: 10.1016/0090-6980(83)90132-6

Comparative biological activities of synthetic leukotriene b4 and its ω-oxidation products

20 OH-LTB4 retains significant biological activity, while 20 COOH-LTB4 shows inactive properties in vivo and in vitro.

1983·69citations·A. Ford-hutchinson et al.·Prostaglandins

Prostaglandins

DOI: 10.1016/0003-2697(83)90349-4

Separation of unlabeled metabolites of arachidonic acid from their deuterium- and tritium-labeled analogs by argentation high-pressure liquid chromatography.

Argentation high-pressure liquid chromatography effectively separates unlabeled and deuterium-labeled arachidonic acid metabolites, reducing unlabeled material to 0.1% or less.

1983·27citations·W. Powell·Analytical biochemistry

Analytical biochemistry

Citations

DOI: 10.18452/15257

Regulation of 5-oxo-ETE synthesis in inflammatory cells

5-oxo-ETE production in inflammatory cells is regulated by oxidative stress, glucose levels, and differentiation, with a 3-fold increase in production observed in undifferentiated myeloid cells.

2005·0citations·Karl-Rudolf Erlemann

DOI: 10.1016/J.PLIPRES.2005.04.002

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE.

5-Oxo-ETE is a strong chemoattractant for eosinophils and neutrophils, potentially playing a role in allergic diseases like asthma, and its development as therapeutic agents may be useful in these diseases.

2005·139citations·W. Powell et al.·Progress in lipid research

Progress in lipid research

DOI: 10.1074/jbc.273.33.20951

Calcium/Calmodulin-dependent Conversion of 5-Oxoeicosanoids to 6,7-Dihydro Metabolites by a Cytosolic Olefin Reductase in Human Neutrophils*

Neutrophils convert 5-oxoeicosanoids to 6,7-dihydro metabolites, which are less potent in calcium mobilization, and both 5-oxoeicosanoid 6-reductase and prostaglandin 13-reductase

1998·16citations·K. Berhane et al.·The Journal of Biological Chemistry

The Journal of Biological Chemistry

DOI: 10.1016/S0006-2952(94)00403-X

Enhancement of leukotriene A4 biosynthesis in neutrophils from patients with rheumatoid arthritis after a single glucocorticoid dose.

A single glucocorticoid dose in rheumatoid arthritis patients increases leukotriene A4 biosynthesis in neutrophils, unexpectedly enhancing inflammation and potentially harming clinical improvement.

1995·17citations·E. Thomas et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/0090-6980(93)90112-K

Metabolism of leukotriene B4 by guinea pig eosinophils.

Guinea pig eosinophils can metabolize leukotriene B4 through omega and beta oxidation, potentially modulating inflammatory reactions by removing the chemoattractant from inflammatory sites.

1993·4citations·W. Mathews et al.·Prostaglandins

Prostaglandins