Novel pharmacological properties of transient potassium currents in central neurons revealed by N-bromoacetamide and other chemical modifiers.

doi:10.1016/s0026-895x(25)10493-8

Paper

Novel pharmacological properties of transient potassium currents in central neurons revealed by N-bromoacetamide and other chemical modifiers.

Published Sep 1, 1995 · Rong-Chi Huang

Molecular pharmacology

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Abstract

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In Vitro Study

Study Snapshot

N-bromoacetamide and other chemical modifiers can modify conserved methionine and histidine residues in central neurons, affecting transient potassium currents in a novel and unexpected manner.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Novel pharmacological properties of transient potassium currents in central neurons revealed by N-bromoacetamide and other chemical modifiers.

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References

Citations

Cholinergic modulation of neuronal excitability in the rat suprachiasmatic nucleus.

Cholinergic modulation of SCN neuron excitability involves multiple receptors and ion channels, potentially fine-tuning its control in different physiological settings.

Diurnal modulation of the Na+/K+-ATPase and spontaneous firing in the rat retinorecipient clock neurons.

The rat suprachiasmatic nucleus neurons exhibit a diurnal rhythm in Na+/K+-ATPase activity, with higher activity during the day and lower activity at night, influencing their spontaneous firing rate.

Modulation by chloramine-T of 4-aminopyridine-sensitive transient outward current in rabbit atrial cells.

Chloramine-T can slow inactivation of native A-type channels in rabbit hearts, potentially contributing to the genesis of arrhythmias.

Voltage- and use-dependent inhibition by amphetamine of field potentials and Na+ current in rat nucleus accumbens neurons

Amphetamine directly inhibits field potentials and Na+ currents in rat nucleus accumbens neurons, suggesting a similar mechanism of action to local anesthetics and antiarrhythmic drugs.

An endogenous inactivating inward-rectifying potassium current in oocytes of Xenopus laevis

An endogenous inward-rectifying potassium current is present in Xenopus laevis oocytes, which can be elicited with negative pulses and partially or completely inactivated at more negative membrane potentials.