3-Hydroxypyridine is reduced with sodium borohydride in the presence of benzyl chloroformate to give 1-benzyloxycarbonyl-5-hydroxy-2-piperideine which is transformed into (+)-pseudoconhydrine and (+)-N-methyl-pseudoconhydrine in five steps involving a lipase-mediated kinetic resolution.

This novel reduction of 3-hydroxypyridine allows for the enantioselective synthesis of (+)-pseudoconhydrine and (+)-N-methylpseudoconhydrine in five steps using lipase-mediated kinetic resolution.

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Novel reduction of 3-hydroxypyridine and its use in the enantioselective synthesis of (+)-pseudoconhydrine and (+)-N-methylpseudoconhydrine

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