Retinoids (RC), alpha‐hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the RC‐induced normalization of cellular differentiation, AHA‐induced exfoliation in hydrophilic areas, and BHA‐induced exfoliation in lipophilic areas. AHA and RC have been combined in a bioengineered molecule (AHA retinoid conjugate, or AHA‐RC) delivering both lactic acid (AHA) and RC in a manner reducing retinoid‐associated irritation.

AHA-RC, a novel retinoid ester, combined with salicylic acid effectively treats acne by normalizing cellular differentiation, exfoliating hydrophilic areas, and reducing retinoid-associated irritation.

Paper

Novel retinoid ester in combination with salicylic acid for the treatment of acne

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