A Novel Synthesis of Nitrofuran-Containing 1,3,4,5-Tetrasubstituted Pyrazoles via 1,3-Dipolar Addition Reaction.

doi:10.1002/CHIN.200722104

Paper

A Novel Synthesis of Nitrofuran-Containing 1,3,4,5-Tetrasubstituted Pyrazoles via 1,3-Dipolar Addition Reaction.

Published Feb 1, 2007 · N. S. Rai, B. Kalluraya

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Abstract

A hitherto unreported novel series of nitrofuran containing 1,3,4,5-tetra substituted pyrazole derivatives are prepared by the 1,3-dipolar cycloaddition reaction between 1-aryl-3-(5-nitro-2-furyl)propynones 1 with 4-substituted-3-aryl sydnones 2. The structures of these compounds are established by elemental analysis, IR, 1 H NMR and mass Spectral data. The new compounds are also screened for their antibacterial and antifungal activity and most of them showed significant activity.

Study Snapshot

This study synthesises novel 1,3,4,5-tetrasubstituted pyrazole derivatives with significant antibacterial and antifungal activity by using 1,3-dipolar cycloaddition reaction between 1-aryl-3-(5-nitro-2-furyl)propynones

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A Novel Synthesis of Nitrofuran-Containing 1,3,4,5-Tetrasubstituted Pyrazoles via 1,3-Dipolar Addition Reaction.

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References

Citations

Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities

Recent advances in synthesis and biological activity of heteroannulated pyrazoles show promise for medicinal chemistry and biomedicine.

An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety

Imidazole-based molecular hybrids and conjugates show potential in overcoming antibiotic resistance in difficult-to-treat infections caused by antibiotic-resistant bacteria.

Four 1-aryl-1H-pyrazole-3,4-dicarboxylate derivatives: synthesis, molecular conformation and hydrogen bonding

1-Phenyl-1H-pyrazole-3,4-dicarboxylic acid and 1-(4-methoxyphenyl)-1H-pyrazole-3,4-dicarbohydrazide form complex hydrogen-bonded framework structures, while dimethyl 1-phenyl-1H-pyr

International Journal of Chemistry and Pharmaceutical Sciences

The International Journal of Chemistry and Pharmaceutical Sciences aims to promote high-quality research in all fields of chemistry and pharmaceutical sciences, with strong emphasis on quality and originality.

Pyrazole and Its Biological Activity

Pyrazole and its derivatives possess a wide range of biological activities, including antibacterial, anti-convulsant, analgesic, antimicrobial, anti-inflammatory, and anti-rheumatic properties.