Paper

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).

Published Nov 13, 2010 · Christina Zimmer, Marieke Hafner, Michael Zender

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

N-(Pyridin-3-yl)benzamides are highly selective inhibitors of human aldosterone synthase (CYP11B2) in vitro, with no inhibition observed for CYP17 and CYP19.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).

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