N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.

Paper

N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.

Published Apr 1, 1993 · G. Menozzi, L. Mosti, P. Schenone

Farmaco

UNKNOWN SJR score

6

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0

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Abstract

The synthesis of a series of N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides by reaction of 1-phenyl-1H-oxepino[4,3-c]pyrazole-4(8H),6(7H)-dione with aromatic primary amines is described. Some amides showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate antiinflammatory, analgesic and antipyretic activities in rats or mice.

In Vitro Study

Study Snapshot

N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides show potential as antiinflammatory, analgesic, and antipyretic agents with platelet antiaggregating activity comparable to acetylsalicylic acid.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.

References

Citations

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Ethyl 1-(3-nitrophenyl)-5-phenyl-3-(phenylcarbamoyl)-1H-pyrazole-4-carboxylate shows the highest antiproliferative activity against Vero, C6, and HeLa cells, with better performance than 5-fluor

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Synthesis and antibacterial activity of some new derivatives of pyrazole

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Synthesis and antinociceptive-antimicrobial activities of some new amide derivatives of 3,5-di/-and 1,3,5-trimethylpyrazoles

New amide derivatives of 3,5-di- and 1,3,5-trimethylpyrazoles show significant antinociceptive activity, but weak antibacterial activity.

ω‐Dialkylaminoalkyl ethers of phenyl‐(5‐substituted 1‐phenyl‐1H‐pyrazol‐4‐yl)methanols with analgesic and anti‐inflammatory activity

Compounds 4i,m-p,s show good analgesic activity and moderate anti-inflammatory activity in mice.