Paper
Oleuropein activated AMPK and induced insulin sensitivity in C2C12 muscle cells.
Published Apr 15, 2016 · Fatma Hadrich, Marie Garcia, Amina Maalej
Life sciences
Q1 SJR score
55
Citations
4
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Oleuropein activates AMPK and induces insulin sensitivity in C2C12 muscle cells, potentially benefiting diabetic patients by enhancing insulin sensitivity through both insulin-dependent and insulin-independent pathways.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis.
Poliothrysoside and its derivatives show potential as promising leads for non-insulin dependent type 2 diabetes by increasing insulin sensitivity and inhibiting adipogenesis.
2014·11citations·K. Sashidhara et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Olive leaf extract suppresses messenger RNA expression of proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with streptozotocin and high-fat diet-induced diabetes.
Olive leaf extract may improve insulin resistance and inflammation in type 2 diabetes rats by suppressing proinflammatory cytokines and increasing insulin receptor substrate 1 expression.
2014·48citations·Yanan Liu et al.·Nutrition research
Nutrition research
Chlorella modulates insulin signaling pathway and prevents high-fat diet-induced insulin resistance in mice.
Chlorella vulgaris prevents high-fat diet-induced insulin resistance in obese mice by improving insulin signaling and reducing triglyceride, cholesterol, and free fatty acid levels.
2014·40citations·J. F. Vecina et al.·Life sciences
Life sciences
Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways.
Mango leaf extract reduces glucose and triglyceride levels in mice by regulating lipid metabolism through the AMPK and PI3K/AKT signaling pathways.
2013·49citations·Yi Zhang et al.·Food chemistry
Food chemistry
Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice.
Olive leaf supplementation effectively reduces oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice, potentially providing therapeutic inhibition of diabetic complications.
2013·31citations·Jung-Hyun Park et al.·Nutrition research
Nutrition research
Citations
Anti-Diabetic Effects of Oleuropein
Oleuropein, found in olive oil and fruit, shows potential anti-inflammatory and anti-diabetic properties by reducing inflammation and improving glucose tolerance and insulin sensitivity.
2024·0citations·Michael Iantomasi et al.·Metabolites
Metabolites
Oleocanthal Protects C2C12 Myotubes against the Pro-Catabolic and Anti-Myogenic Action of Stimuli Able to Induce Muscle Wasting In Vivo
Oleocanthal protects C2C12 myotubes from muscle wasting stimuli by restoring their size, morphology, and normal levels of atrogin-1 and MuRF1.
2024·0citations·Daniela De Stefanis et al.·Nutrients
Nutrients
Oleuropein-Rich Jasminum Grandiflorum Flower Extract Regulates the LKB1-PGC-1α Axis Related to the Attenuation of Hepatocellular Lipid Dysmetabolism
Oleuropein-rich extract from Jasminum grandiflorum flowers reduces hepatic lipid deposition in high-fat diet-fed mice and may help prevent and treat metabolic diseases by regulating the LKB1-PGC-1 axis.
2023·1citation·Yajun Hou et al.·Nutrients
Nutrients
In silico Study to Optimize the Dosage of Oleuropein with Metformin in Diabetes Management
The optimal combination of 300mg of metformin and 500mg of oleuropein effectively treats type 2 diabetes, ensuring a 2% improvement in GLUT4 concentration and reducing metformin dose.
2023·0citations·D. M. Joshi et al.·Iraqi Journal of Science
Iraqi Journal of Science
Potential anticancer activity of chemically characterized extract of Olea europaea (Olive) leaves
Olive leaf extract shows potential anticancer activity, inhibiting cell proliferation and promoting apoptosis in human lung cancer (A549) cell lines.
2023·4citations·Shehla Nasar Mir Najibullah et al.·Emirates Journal of Food and Agriculture
Emirates Journal of Food and Agriculture
Dietary Vitamin E and/or Hydroxytyrosol Supplementation to Sows during Late Pregnancy and Lactation Modifies the Lipid Composition of Colostrum and Milk
Dietary vitamin E and/or hydroxytyrosol supplementation to sows during late pregnancy and lactation improves piglets' oxidative status, potentially promoting gut health and growth during the first weeks of life.
2023·4citations·Hernán D Laviano et al.·Antioxidants
Antioxidants
Antihyperglycemic Properties of Extracts and Isolated Compounds from Australian Acacia saligna on 3T3-L1 Adipocytes
Australian Acacia saligna extracts and compounds can reduce oxidative stress, improve mitochondrial function, and enhance glucose uptake in adipocytes, supporting their potential antidiabetic application.
2023·1citation·A. Asmara et al.·Molecules
Molecules
Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota
Hydroxytyrosol and oleuropein, found in extra virgin olive oil, may help prevent age-related neurodegeneration, skeletal muscle dysfunction, and gut microbiota imbalances.
2023·28citations·L. Micheli et al.·Nutrients
Nutrients
The Oleoside-type Secoiridoid Glycosides: Potential Secoiridoids with Multiple Pharmacological Activities
Oleoside-type secoiridoid glycosides, found in the Oleaceae family, exhibit various pharmacological activities, including antioxidative, antitumor, anti-inflammatory, and neuroprotective effects.
2023·2citations·Baoyi Fu et al.·Journal of Molecular Structure
Journal of Molecular Structure