One-pot enzyme cascade for controlled synthesis of furan carboxylic acids from 5-hydroxymethylfurfural via H2O2 internal recycling.

doi:10.1002/cssc.201902199

Paper

One-pot enzyme cascade for controlled synthesis of furan carboxylic acids from 5-hydroxymethylfurfural via H2O2 internal recycling.

Published Nov 8, 2019 · Hao‐Yu Jia, Min-hua Zong, G. Zheng

ChemSusChem

Q1 SJR score

43

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0

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Abstract

Furan carboxylic acids are promising biobased building blocks in pharmaceutical and polymer industries. In this work, dual-enzyme cascade systems composed of galactose oxidase (GOase) and alcohol dehydrogenases (ADHs) were constructed for controlled synthesis of 5-formyl-2-furancarboxylic acid (FFCA) and 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF), based on the catalytic promiscuity of ADHs. The byproduct H 2 O 2 produced in GOase-catalyzed oxidation of HMF to 2,5-diformylfuran (DFF) was used for horseradish peroxidase (HRP)-mediated regeneration of the oxidized nicotinamide cofactors for subsequent oxidation of DFF promoted by an ADH, thus implementing H 2 O 2 internal recycling. The desired products FFCA and FDCA were obtained with the yields of more than 95%.

Study Snapshot

This study developed a one-pot enzyme cascade for controlled synthesis of furan carboxylic acids from 5-hydroxymethylfurfural, achieving over 95% yields and implementing H2O2 internal recycling.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

One-pot enzyme cascade for controlled synthesis of furan carboxylic acids from 5-hydroxymethylfurfural via H2O2 internal recycling.

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References

Biosynthesis of 2,5-furan dicarboxylic acid by Aspergillus flavus APLS-1: Process optimization and intermediate product analysis.

This paper has been retracted due to violations of the journal's authorship and conflict of interest policies, but the authors dispute the grounds for the retraction.

Highly efficient and selective production of FFCA from CotA-TJ102 laccase-catalyzed oxidation of 5-HMF.

CotA-TJ102 laccase from Bacillus subtilis TJ-102 efficiently and selectively converts 5-HMF to FFCA, offering a promising green production method for fuels, chemical intermediates, and drugs.

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

HmfF can catalyze furoic acid carboxylation at elevated CO2 levels, offering a potential alternative to petrochemical-derived monomers in PET plastics.

Myoglobin-Catalyzed Efficient In Situ Regeneration of NAD(P)+ and Their Synthetic Biomimetic for Dehydrogenase-Mediated Oxidations

Myoglobin-catalyzed regeneration of NAD(P)+ and their synthetic biomimetic BNAH with H2O2 offers potential for efficient cofactor recycling in various dehydrogenase-mediated oxidations.

Catalytic carbonylation of renewable furfural derived 5-bromofurfural to 5-formyl-2-furancarboxylic acid in oil/aqueous bi-phase system

This study presents a novel catalytic carbonylation method for synthesis of 5-formyl-2-furancarboxylic acid (FFA) from renewable furfural derived 5-bromofurfural, offering a potential large-scale production opportunity.

Citations

Recent Trends in the Synthesis of Monomers for Furanoate Polyesters and Their Nanocomposites’ Fabrication as a Sustainable Packaging Material

Furanoate-based nanocomposites offer eco-friendly, sustainable packaging materials with enhanced performance characteristics, making them suitable for various industrial applications.

Biocatalytic approach for the synthesis of chiral alcohols for the development of pharmaceutical intermediates and other industrial applications: A review.

Biocatalysis offers shorter, more efficient, and sustainable pathways for the synthesis of active pharmaceutical ingredients, with potential for non-pharmaceutical applications.

Co-immobilization of galactose oxidase, catalase, and Mn-superoxide dismutase for efficient conversion of 5-hydroxymethylfurfural to 2,5-diformylfuran in water.

The co-immobilization of galactose oxidase, catalase, and Mn-superoxide dismutase on Cu II in phosphate buffer saline effectively converts 5-hydroxymethylfurfural to 2,5-diformylfuran in water,

Efficient Synthesis of Furfuryl Alcohol from Corncob in a Deep Eutectic Solvent System

This hybrid strategy combines chemocatalysis and biocatalysis to efficiently convert lignocellulosic biomass into valuable biofurans, such as furfuryl alcohol, for use in resins, vitamins, and fuel additives.

Chemoenzymatic Conversion of Biomass-Derived D-Xylose to Furfuryl Alcohol with Corn Stalk-Based Solid Acid Catalyst and Reductase Biocatalyst in a Deep Eutectic Solvent–Water System

Chemoenzymatically transforming biomass-derived D-xylose to furfuryl alcohol using corn stalk-based solid acid catalyst and reductase biocatalyst in a deep eutectic solvent-water system can produce sustainable value-added furan-based chemicals from renewable

Optimizing operational parameters for the enzymatic production of furandicarboxylic acid building block

Optimizing operational parameters for hydroxymethylfurfural oxidase (HMFO) can increase the production of 2,5-Furandicarboxylic acid (FDCA) from bio-based 5-hydroxymethylfurfural (HMF) into a green plastic precursor.

Conversion of organosolv pretreated hardwood biomass into 5-hydroxymethylfurfural (HMF) by combining enzymatic hydrolysis and isomerization with homogeneous catalysis

This study demonstrates the feasibility of producing HMF from lignocellulose in an environmentally friendly manner, using enzymatic hydrolysis, isomerization, and homogeneous catalysis.