Paper
One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile
Published Jan 1, 2020 · M. A. Radwan, F. Alminderej, H. Awad
Molecules
Q1 SJR score
19
Citations
0
Influential Citations
Abstract
A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine. The cytotoxic activity of the new synthesized tetrazolopyrimidine-6-carbonitrile compounds was investigated against HCT-116, MCF-7, MDA-MB-231, A549 human cancer cell lines and one human healthy normal cell line (RPE-1) using the MTT cytotoxicity assay. Compounds 4h, 4b, 4c, 4i and 4a showed potent anticancer activities against human colon cancer. Additionally, all the compounds showed potent anticancer activities on human lung cancer.
In Vitro StudyStudy Snapshot
Novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile compounds show potent anticancer activities against human colon cancer and lung cancer.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
An efficient regioselective three-component synthesis of tetrazoloquinazolines using g-C3N4 covalently bonded sulfamic acid
This study developed a green, cost-effective, and one-pot method for synthesis of tetrazoloquinazolines using covalently bonded sulfamic acid graphitic carbon nitride, offering advantages such as high efficiency, mild conditions, and reusability.
2019·21citations·A. Hassankhani et al.·Polyhedron
Polyhedron
An efficient, multicomponent, green protocol to access 4, 7-dihydrotetrazolo [1, 5-a] pyrimidines and 5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones using PEG-400 under microwave irradiation
This study presents a green, efficient, and simple method for synthesis of dihydrotetrazolo[1,5-a]pyrimidines and tetrahydrotetrazolo[5,1-b]quinazolinones using PEG-400 under microwave irradi
2019·19citations·Shaik Firoj Basha et al.·Synthetic Communications
Synthetic Communications
DNA profiling and in vitro cytotoxicity studies of tetrazolo[1,5-a]pyrimidine-based copper(II) complexes
Copper(II) complexes synthesized from tetrazolo[1,5-a]pyrimidine show potential as anti-cancer agents, with potential cytotoxicity against various cancer cell lines and normal cells.
2019·7citations·A. Haleel et al.·BioMetals
BioMetals
Tetrazoles via Multicomponent Reactions
Multicomponent reactions offer novel, diverse, and complex pathways for preparing substituted tetrazole derivatives, offering potential for novel drug design and improved understanding of their receptor binding modes.
2019·364citations·Constantinos G. Neochoritis et al.·Chemical Reviews
Chemical Reviews
An efficient cascade synthesis of substituted 6,9-dihydro-1H-pyrazolo[3,4-f]quinoline- 8-carbonitriles
This efficient cascade synthesis of substituted 6,9-dihydro-1H-pyrazolo[3,4-f]quinoline-8-carbonitriles is a promising strategy for the efficient synthesis of complex organic compounds.
2018·4citations·Hong-Lei Li et al.·Heterocyclic Communications
Heterocyclic Communications
Cyto-toxicity, biocompatibility and cellular response of carbon dots–plasmonic based nano-hybrids for bioimaging
Carbon dots-plasmonic nano-hybrids show enhanced optical properties and biocompatibility, making them safe for diagnostic bioimaging applications.
2017·105citations·A. Emam et al.·RSC Advances
RSC Advances
Multicomponent Condensation Reactions via ortho-Quinone Methides.
Two- and three-component strategies using ortho-quinone methide intermediates provide efficient access to benzopyrans in good yields and selectivities.
2017·41citations·E. E. Allen et al.·Organic letters
Organic letters
Synthesis of Polysubstituted 3-Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction.
This novel palladium-catalyzed three-component tandem reaction effectively synthesizes polysubstituted 3-amino pyrroles with moderate to excellent yields under mild conditions, making it a promising method for synthesis of 3-phenyl-1,4-dihydropyr
2017·37citations·Jianwen Peng et al.·The Journal of organic chemistry
The Journal of organic chemistry
Synthesis of Diastereoenriched Oxazolo[5,4-b]indoles via Catalyst-Free Multicomponent Bicyclizations.
This eco-friendly method for synthesis of diverse and functionalized oxazolo[5,4-b]indoles with high diastereoselectivity from readily available arylglyoxals and amino acids in ethanol enables rapid building up of functional N,O-hetero
2017·43citations·Lu Wang et al.·The Journal of organic chemistry
The Journal of organic chemistry
Citations
Novel Indeno-Pyrazole and Indeno-Pyrimidine Conjugates: Synthesis, DFT, Anticancer Screening and In Silico Studies as Potent Tubulin Inhibitors
Novel indeno-pyrazole and indeno-pyrimidine conjugates show promising anticancer activity and favorable interaction with tubulin, making them viable therapeutic candidates.
2024·0citations·Dina H. Elnaggar et al.·Journal of Molecular Structure
Journal of Molecular Structure
Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole
5-Aminotetrazole is a versatile and effective building block for the synthesis of heterocyclic compounds, with potential applications in biologically active and industrially important compounds.
2023·5citations·Ramin Javahershenas et al.·Synthesis
Synthesis
Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update
3-cyanoacetyl indoles (CAIs) are versatile starting materials for the synthesis of various heterocyclic compounds with potential biological and pharmaceutical activities.
2023·0citations·Abolfazl Olyaei et al.·RSC Advances
RSC Advances
Multi-Component Synthesis of Indole-Substituted Heterocycles– A Review
Indole derivatives can be effectively used in multi-component reactions for the synthesis of indole-substituted heterocycles, offering potential medicinal and biological properties.
2023·7citations·Rogheyeh Hossein Nia et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
New tetrazoles compounds incorporating galactose moiety: Synthesis, crystal structure, spectroscopic characterization, Hirshfeld surface analysis, molecular docking studies, DFT calculations and anti-corrosion property anticipation
New tetrazole compounds incorporating galactose moiety show potential anti-corrosion properties, with experimental results correlating to calculated ones and showing great compatibility.
2022·13citations·Riham Sghyar et al.·Journal of Molecular Structure
Journal of Molecular Structure
15N Chemical Shifts and JNN-Couplings as Diagnostic Tools for Determination of the Azide-Tetrazole Equilibrium in Tetrazoloazines.
Combining 15N chemical shifts and JNN-couplings in selectively isotope-enriched compounds provides an effective diagnostic tool for determining the azido-tetrazole equilibrium in tetrazoloazines.
2021·5citations·S. Deev et al.·The Journal of organic chemistry
The Journal of organic chemistry
Assessment of the Antimicrobial and Antiproliferative Activities of Chloropyrazine-Tethered Pyrimidine Derivatives: In Vitro, Molecular Docking, and In-Silico Drug-Likeness Studies
Chloropyrazine-tethered pyrimidine derivatives show superior antiproliferative activity, with compound 35 showing potential as a lead molecule for developing new anticancer drugs.
2021·10citations·Richie R. Bhandare et al.·Applied Sciences
Applied Sciences
Application of polyionic magnetic nanoparticles as a catalyst for the synthesis of carbonitriles with both indole and triazole moieties via a cooperative geminal-vinylogous anomeric-based oxidation
Polyionic magnetic nanoparticles effectively catalyze the synthesis of 7-aryl-5-(1H-indol-3-yl)-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles via a cooperative geminal-viny
2021·3citations·Mohammad Dashteh et al.·Molecular Diversity
Molecular Diversity
A Three-Component Process for the Synthesis of Tetrazolo[1,5-a]Pyrimidine-6-Carbonitrile Derivaties Using Amino-Functionalized UiO-66(Zr) Metal Organic Framwork (MOF)
UiO-66-NH2 metal organic framework effectively catalyzes the synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles at 100°C under solvent-free conditions, making it cost-effective and eco-friendly.
2021·7citations·M. H. Abdollahi-Basir et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds