Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives.

doi:10.1016/j.bmc.2010.02.028

Paper

Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives.

Published Apr 1, 2010 · A. Hussein, O. Ahmed

Bioorganic & medicinal chemistry

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Abstract

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Study Snapshot

The novel tetrazolo[1,5-a]pyrimidine derivative 6b shows anti-tumor effects against Ehrlich ascites carcinoma and hepatocellular carcinoma, likely due to cell cycle arrest and apoptosis through down-regulation of Bcl-2 and up-regulation of

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives.

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References

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

New pyridine and pyrazolo[1,5-a]pyrimidine derivatives show potent anti-tumor cytotoxic activity in vitro using various human cancer cell lines.

Synthesis and Biological Evaluation of Some Novel Polysubstituted Pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents

Polysubstituted pyrimidine derivatives show potential as dual antimicrobial-anticancer agents, with compounds 1, 2, 6, 7, 9, and 24 showing broad antibacterial spectrum profiles and cytotoxic activity against various human cancer cell lines.

Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.

This study identified novel, water-soluble A2A receptor antagonists with excellent solubility and in vivo efficacy in a rodent model of Parkinson's disease.

Synthesis of some pyrazolopyrimidines as purine analogues

Pyrazolo[1,5-a]pyrimidines, purine analogues, were synthesized using 3-aminopyrazoles and various synthesis methods.

Molecular targets of dietary agents for prevention and therapy of cancer.

Dietary agents found in fruits and vegetables can interfere with multiple cell-signaling pathways, potentially preventing and treating cancer and other diseases.

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