A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones.

doi:10.1021/JO034593I

Paper

A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones.

Published Sep 6, 2003 · Sungmin Cho, Yong-Dae Park, Jeum‐Jong Kim

The Journal of organic chemistry

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43

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0

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Abstract

Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyridines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.

Study Snapshot

This one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones provides excellent yields by using cesium carbonate in refluxing acetonitrile, with Smiles rearrangement and subsequent cyclization.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones.

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References

Citations

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Synthesis, structure and biological activity 3- (arylmethyl) aminopyridine-2 (1 H ) -ones and 1 H -pyrido[2,3-b][1,4]oxazin-2(3 H )-ones

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The one-pot synthesis of novel isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones using [HMIm]BF4 as green solvent is efficient and environmentally friendly, yielding high yields and easy recovery.

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