Paper
One-Pot Three-Component Condensations of 2,6-Diaminopyrimidin-4(3H)-one, Aromatic Aldehydes, and Naphthols. Synthesis of Isomeric Benzochromeno[2,3-d]pyrimidines
Published Jul 1, 2020 · A. Harutyunyan, S. G. Israyelyan, H. Panosyan
Russian Journal of Organic Chemistry
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Abstract
One-pot three-component reactions of 2,6-diaminopyrimidin-4-(3H)-one with aromatic aldehydes and 1- or 2-naphthol afforded benzo[7,8]chromeno[2,3-d]pyrimidine and benzo[5,6]chromeno[2,3-d]pyrimidine derivatives, respectively. In both cases, the heterocyclization involved substitution of the 6-amino group of 2,6-diaminopyrimidin-4-(3H)-one by hydroxy group of naphthol and closure of 4H-pyran ring, whereas no alternative benzopyrimidoquinoline derivatives were formed.
One-pot reactions of 2,6-diaminopyrimidin-4-(3H)-one, aromatic aldehydes, and naphthol result in isomeric benzo[7,8]chromeno[2,3-d]pyrimidine and benzo[5,6]chromen
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