Organophosphate inhibitors: the reactions of bis(p-nitrophenyl) methyl phosphate with liver carboxylesterases and alpha-chymotrypsin.

doi:10.1016/0005-2744(75)90310-1

Paper

DOI: 10.1016/0005-2744(75)90310-1

Organophosphate inhibitors: the reactions of bis(p-nitrophenyl) methyl phosphate with liver carboxylesterases and alpha-chymotrypsin.

Published Feb 19, 1975 · S. Hamilton, A. Dudman, J. de Jersey

Biochimica et biophysica acta

UNKNOWN SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Bis(p-nitrophenyl) methyl phosphate rapidly reacts with chicken, sheep, and horse liver carboxylesterases, but more slowly with -chymotrypsin, producing stable phosphorylated enzymes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/0005-2744(74)90157-0

The inhibition of acetylcholinesterase by organophosphorus compounds containing a PCl bond

Organophosphorus compounds containing a PCl bond can effectively inhibit acetylcholinesterase, with methyl phosphonodichloridate being significantly more potent than difluoridate.

1974·21citations·P. Wins et al.·Biochimica et Biophysica Acta

Biochimica et Biophysica Acta

DOI: 10.1016/0006-291X(73)91359-4

The involvement of histidine in the action of liver carboxylesterases.

Chicken and ox liver carboxylesterases are irreversibly inhibited by -bromoacetophenone, leading to radioactive products like 1- and 3-phenacylhistidines.

1973·10citations·P. Willadsen et al.·Biochemical and biophysical research communications

Biochemical and biophysical research communications

DOI: 10.1016/0003-2697(71)90432-5

Determination of methanol and its application to measurement of pectin ester content and pectin methyl esterase activity.

This study presents a simple and precise spectrophotometric method for determining methanol in pectin samples, improving on previous methods for pectin and pectin esterase metabolism studies.

1971·332citations·P. Wood et al.·Analytical biochemistry

Analytical biochemistry

DOI: 10.1021/BI00833A034

Carboxylesterases (EC 3.1.1). The molecular weight and equivalent weight of pig liver carboxylesterase.

Pig liver carboxylesterase has a molecular weight of 163,000 and two active sites per molecular weight, with slow inactivation at pH 5, but dissociation into half-molecules at pH 7.5.

1969·44citations·D. J. Horgan et al.·Biochemistry

Biochemistry

DOI: 10.1021/BI00833A037

Carboxylesterases (EC 3.1.1). Kinetic studies on carboxylesterases.

Pig liver carboxylesterase catalyzes the hydrolysis of butyrate esters, forming an acyl-enzyme intermediate and showing activation by substrate and modifiers, suggesting different essential chemistry between esterases and proteinases.

1969·75citations·J. K. Stoops et al.·Biochemistry

Biochemistry

DOI: 10.1016/0003-9861(67)90006-9

Ageing and dealkylation of Soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesterase.

Ageing and dealkylation of Soman-inactivated electric eel cholinesterase occur at identical rates, with the enzyme's acidic group catalyzing the process.

1967·101citations·H. Michel et al.·Archives of biochemistry and biophysics

Archives of biochemistry and biophysics

Citations

DOI: 10.1016/j.cbi.2016.02.011

Carboxylesterases: General detoxifying enzymes.

Carboxylesterases act as a general detoxifying enzymes, able to hydrolyze ester-containing xenobiotics and are irreversibly inhibited by organophosphates like Sarin and Tabun.

2016·119citations·M. Hatfield et al.·Chemico-biological interactions

Chemico-biological interactions

DOI: 10.1016/j.etap.2004.12.048

Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action.

Cholinesterase inhibitors, which modify cholinergic signaling, have diverse uses in treating human diseases, controlling insect pests, and as chemical warfare agents and weapons of terrorism.

2005·293citations·C. Pope et al.·Environmental toxicology and pharmacology

Environmental toxicology and pharmacology

DOI: 10.1016/S0167-4838(96)00116-1

New catalytic roles for serine esterases: a 19F-NMR study of the interaction of 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-1-propanone with chicken liver carboxylesterase.

Chicken liver carboxylesterase catalyzes the cleavage of TDPP to yield fluoride ion or trifluoroacetate, and also benzilic acid rearrangement to -trifluoromethylmandelai.e.

1996·1citation·M. Bowles et al.·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1080/03086647908077472

TRANSESTERIFICATION OF TRIS(p-NITROPHENYL) PHOSPHATE WITH SODIUM ALKOXIDES: BIS(p-NITROPHENYL) METHYL PHOSPHATE, BIS(p-NITROPHENYL) BENZYL PHOSPHATE, BIS(p-NITROPHENYL) n-BUTYL PHOSPHATE

Transesterification of tris(p-nitrophenyl) phosphate with sodium alkoxides provides a convenient synthetic route to diaryl alkyl phosphates in high purity and moderate to high yields.

1979·1citation·M. Berndt et al.·Phosphorus Sulfur and Silicon and The Related Elements

Phosphorus Sulfur and Silicon and The Related Elements

DOI: 10.1016/0005-2744(77)90144-9

Organophosphate inhibitors. The stereospecificity of hydrolysis of methyl n-butyl p-nitrophenyl phosphate by serum phosphotriesterases (EC 3.1.1.2) and by acetylcholinesterases (EC 3.1.1.7).

Serum phosphotriesterases cannot prevent acute phosphotriester poisoning or regenerate active enzyme from phosphorylated acetylcholinesterase, but can help in chronic exposure by hydrolyzing organophosphate poisons in the blood.

1977·4citations·N. Dudman et al.·Biochimica et biophysica acta

Biochimica et biophysica acta