Oxocarbon Acids and their Derivatives in Biological and Medicinal Chemistry.

doi:10.2174/0929867330666230313141452

Paper

Oxocarbon Acids and their Derivatives in Biological and Medicinal Chemistry.

Published Mar 13, 2023 · J. Honek, Amanda Ratto

Current medicinal chemistry

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Abstract

The biological and medicinal chemistry of the oxocarbon acids 2,3-dihydroxycycloprop-2-en-1-one (deltic acid), 3,4-dihydroxycyclobut-3-ene-1,2-dione (squaric acid), 4,5-dihydroxy-4-cyclopentene-1,2,3-trione (croconic acid), 5,6-dihydroxycyclohex-5-ene-1,2,3,4-tetrone (rhodizonic acid) and their derivatives is reviewed and their key chemical properties and reactions are discussed. Applications of these compounds as potential bioisosteres in biological and medicinal chemistry are examined. Reviewed areas include cell imaging, bioconjugation reactions, antiviral, antibacterial, anticancer, enzyme inhibition, and receptor pharmacology.

Study Snapshot

Oxocarbon acids and their derivatives show potential as bioisosteres in biological and medicinal chemistry, including cell imaging, bioconjugation reactions, antiviral, antibacterial, anticancer, enzyme inhibition, and receptor pharmacology.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Oxocarbon Acids and their Derivatives in Biological and Medicinal Chemistry.

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