Crystal packing and crystallization tendency from the melt of 2-((2-ethylphenyl)amino)nicotinic acid

doi:10.1515/ZKRI-2017-2070

Paper

Crystal packing and crystallization tendency from the melt of 2-((2-ethylphenyl)amino)nicotinic acid

Published Sep 19, 2017 · Arjun Kalra, Mingtao Zhang, S. Parkin

Zeitschrift für Kristallographie - Crystalline Materials

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Abstract

Abstract 2-((2-ethylphenyl)amino)nicotinic acid (2EPNA) was synthesized and its crystal structure was determined. It was observed that alkylation of the phenyl ring with ethyl group disrupts the planar conformation of the molecule by steric repulsion, resulting in formation of an acid-pyridine heterosynthon (instead of acid-acid homosynthon) in the crystal. Crystallization tendency from the melt state of the polymorph was studied by differential scanning calorimetry (DSC). It was revealed that this compound could form a very stable amorphous phase on melt quenching and not crystallize even on re-heating. The formation of acid-pyridine hydrogen bonding in the amorphous state is believed to be responsible for its good glass forming ability.

Study Snapshot

2-((2-ethylphenyl)amino)nicotinic acid (2EPNA) can form a stable amorphous phase on melt quenching, with acid-pyridine hydrogen bonding responsible for its good glass-forming ability.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Crystal packing and crystallization tendency from the melt of 2-((2-ethylphenyl)amino)nicotinic acid

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Citations

Phase Transition Enthalpy Measurements of Organic Compounds. An Update of Sublimation, Vaporization, and Fusion Enthalpies from 2016 to 2021

This update includes new fusion, vaporization, and sublimation enthalpies for organic compounds, as well as an update on polyaromatic hydrocarbons, and provides transition temperatures for about 1100 molecules.

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Phenylethyl phenylacetate derivatives and analogues can form supercooled liquids with supercooling degrees as high as 44°C, making them potential for thermal energy control in appropriate working temperature regions.