Paper
Palladium‐Catalyzed Amination and Sulfonylation of 5‐Bromo‐3‐[2‐(diethylamino)ethoxy]indoles to Potential 5‐HT6 Receptor Ligands
Published Nov 1, 2008 · N. Schwarz, A. Pews-Davtyan, D. Michalik
European Journal of Organic Chemistry
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Abstract
A general and efficient palladium-catalyzed amination of 5-bromo-3-[2-(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)2 and 2-[di(1-adamantyl)phosphanyl]-1-phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivatives, which are of interest as potentially biological active 5-HT6 receptor ligands.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Palladium-catalyzed amination of 5-bromo-3-[2-(diethylamino)ethoxy]indoles leads to novel indole derivatives, potentially biological active 5-HT6 receptor ligands.
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