A new synthetic method of N-methoxy-N-methylamides is developed. The palladium-catalyzed coupling reaction of N-methoxy-N-methylcarbamoyl chloride furnished N-methoxy-N-methylamide in moderate to good yield, wherein a carbonyl equivalent was appended to sp and sp2 carbon atoms as a versatile synthetic basis for further manipulation.

The palladium-catalyzed coupling reaction of N-methoxy-N-methylcarbamoyl chloride provides a versatile synthetic basis for further manipulation of N-methoxy-N-methylamides.

Paper

Palladium-Catalyzed Coupling Reactions of N-Methoxy-N-methylcarbamoyl Chloride for the Synthesis of N-Methoxy-N-methylamides.

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