Paper
Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins.
Published Aug 16, 2017 · Guangbin Jiang, Jianxiao Li, Chuanle Zhu
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59
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1
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Abstract
An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C-H functionalization procedure.
Study Snapshot
Palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids efficiently prepares 3-substituted isocoumarins with stereo- and regioselective properties.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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