The tandem synthesis of 2-trifluoromethylthio(seleno)-substituted benzofurans using palladium-catalyzed conditions is reported. Trifluoromethylthio(seleno)lation of 2-(2,2-dibromovinyl)phenols with (bpy)CuSCF3 or [(bpy)CuSeCF3]2 furnishes several 2-trifluoromethylthio(seleno)lated benzofurans in acceptable to good yield. Mechanistic investigations were performed to elucidate the reaction pathway, which was involved in the formation of a 2-bromobenzofuran species. The scope of this protocol was further extended to the preparation of 2-trifluoromethylthio(seleno)lated benzothiophenes and indoles.

Palladium-catalyzed tandem synthesis of 2-trifluoromethylthio(seleno)-substituted benzofurans provides acceptable to good yields, with potential applications in the preparation of 2-trifluoromethylthio(seleno)lated benzothi

Paper

Palladium-Catalyzed Tandem Synthesis of 2-Trifluoromethylthio(seleno)-Substituted Benzofused Heterocycles.

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