Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice

doi:10.1016/0278-5846(94)90132-5

Paper

Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice

Published Oct 1, 1994 · Olga Valverderk, J. Micó, R. Maldonado

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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93

Citations

2

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Tricyclic antidepressants reduce pain in mice partly by activating the endogenous opioid system and partly by activating noradrenergic and serotonergic pathways, with analgesic responses depending on the analgesimeter used.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice

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References

Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice

Antidepressants in Cancer Pain

Desipramine modulation of σ and opioid peptide receptor expression in glial cells

Evidence for a central but not a peripheral analgesic effect of clomipramine in rats

Possible mechanisms of morphine analgesia.

Citations

Ten-year analgesic utilization patterns and economic implications in Portugal.

Portugal experienced a major increase in both weak and strong opioid prescriptions from 2012-2022, aligning with Spain and Denmark.

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Antidepressants effectively reduce chronic pain, with tricyclic antidepressants being more effective than SSRIs and SNRIs.

Effect of Nortriptyline on Spreading Depolarization

Nortriptyline increases spreading depolarization in the brain by increasing extracellular potassium collection, potentially causing more neuronal depolarization and enhancing spreading depolarization waves.

Relative prevalence of 10 types of pharmacodynamic interactions in psychiatric treatment

Pharmacodynamic interactions in psychiatric treatment are not consistently affected by medical evidence or Micromedex warnings, with prescription frequency not significantly influenced.

Evaluation of central and peripheral analgesic activity of amitriptyline in mice

Amitriptyline has significant analgesic activity in mice, mediated by modulation of both central and peripheral pathways.