A simple palladium-catalyzed one-pot synthesis of 2-substituted 1,5-dihydrobenzo[ e ][1,2,4]- oxadiazepines from corresponding ( E )-amidoximes and o -iodobenzyl bromide or 2-bromo-3-chloromethylpyridine is described. Of the derivatives prepared 2-[6-(quinolin-2-ylsulfanyl)- hexyl]-1,5-dihydrobenzo[ e ][1,2,4]oxadiazepine exhibits high activity on HT-1080 (hyman fibro-sarcoma) and MG-22A (mouse hepatoma) cancer cell lines.

Palladium-catalyzed one-pot synthesis of 2-substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines demonstrates high activity against HT-1080 and MG-22A cancer cell lines.

Arkivoc

A new pathway for the preparation of biologically active 2 substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine

Paper

A new pathway for the preparation of biologically active 2 substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine

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