Pentaerythritol as the core of multivalent glycolipids: synthesis of a glycolipid with three SO3Lea ligands.

doi:10.1021/OL0514202

Paper

DOI: 10.1021/OL0514202

Pentaerythritol as the core of multivalent glycolipids: synthesis of a glycolipid with three SO3Lea ligands.

Published Jul 19, 2005 · J. Xue, Junmin Zhu, R. Marchant

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Abstract

A glycolipid containing three SO(3)Le(a) ligands was synthesized with pentaerythritol as the core. The glycolipid was used to prepare glycoliposomes that showed stability similar to that of DSPC liposomes without glycolipid. The easily prepared derivatives of pentaerythritol proved to be useful scaffolds for multivalent displaying of carbohydrates in the form of glycolipids and clustered glycoliposomes. [structure: see text]

Study Snapshot

Pentaerythritol-based glycolipids with three SO(3)Le(a) ligands show potential as stable scaffolds for multivalent displaying of carbohydrates in glycolipids and clustered glycoliposomes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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