Paper
Peptide synthesis with benzisoxazolium salts—II : Activation chemistry of 2-ethyl-7-hydroxybenzisoxazolium fluroborate; Coupling chemistry of 3-acyloxy-2-hydroxy-N-ethylbenzamides
Published 1974 · D. Kemp, S. W. Wang, J. Rebek
Tetrahedron
Q3 SJR score
17
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
The 2-ethyl-7-hydroxybenzisoxazolium fluoroborate-based method effectively synthesizes amino acid derivatives, with low racemization due to an internal buffering effect.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
The N-ethylbenzisoxazolium cation—II: The mechanism of reactions of the cation with nucleophiles
The N-ethylbenzisoxazolium cation undergoes a ready general base-catalyzed internal elimination to form a transitory N-ethylbenzoketoketenimine, with high selectivity in combination reactions involving water and acetate
1967·17citations·D. Kemp·Tetrahedron
Tetrahedron
Chemistry of lac resin—VII : Pure lac resin—3: Structure☆☆☆
Pure lac resin is based on terpenic acids (jalaric acid) and aleuritic acid in a 1:1 ratio, supporting the most plausible structure 11.
1974·28citations·A. N. Singh et al.·Tetrahedron
Tetrahedron
Peptide synthesis with benzisoxazolium salts—III : Utility of 7-hydroxy-2-ethylbenzisoxazolium fluoroborate in the synthesis of peptides
The 7-hydroxy-2-ethylbenzisoxazolium fluoroborate method is useful for forming amide bonds in peptide synthesis, with potential for medium-sized peptide synthesis.
1974·24citations·D. Kemp et al.·Tetrahedron
Tetrahedron
The N-ethylbenzisoxazolium cation—I
The N-ethylbenzisoxazolium cation rapidly reacts in aqueous solution with various nucleophiles, yielding unusual substances that can serve as starting materials for the synthesis of hitherto-inaccessible systems.
1965·58citations·D. Kemp et al.·Tetrahedron
Tetrahedron
Citations
Peptide Chain Elongation Using Unprotected Amino Acids in a Micro-flow Reactor.
Peptide chain elongation using unprotected amino acids in a micro-flow reactor effectively suppresses undesired racemization, resulting in good to high yields with less wasteful and toxic reagents.
2019·23citations·Shinichiro Fuse et al.·Chemistry
Chemistry
A Quantitative Analysis of Factors Influencing Ease of Formation and σ-Bonding Strength of Oxa- and Thia-N-Heterocyclic Carbenes.
The nature and ring position of oxygen and sulfur significantly influence the ease of formation and -bonding strength of neutral and anionic N-heterocyclic carbenes.
2017·16citations·C. Ramsden et al.·The Journal of organic chemistry
The Journal of organic chemistry
α‐N‐Protected dipeptide acids: a simple and efficient synthesis via the easily accessible mixed anhydride method using free amino acids in DMSO and tetrabutylammonium hydroxide
This study presents a simple and efficient method for synthesis of N-protected dipeptide acids using free amino acids in DMSO and tetrabutylammonium hydroxide, reducing the need for protecting groups and enabling scalable production of larger peptides.
2013·6citations·G. Verardo et al.·Journal of Peptide Science
Journal of Peptide Science
A series of lysyldipeptide derivatives for racemization studies in peptide synthesis.
In polar solvents, valyl and isoleucyl residues racemize more readily than other residues in lysyldipeptide derivatives.
2009·31citations·N. Benoiton et al.·International journal of peptide and protein research
International journal of peptide and protein research
Application of 1,1,3,3-tetramethylguanidine in the reaction of amino acids with pantolactone
1,1,3,3-tetramethylguanidine effectively reacted amino acids with pantolactone, producing N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)aminoacids without racemization of amino acids.
2004·4citations·M. Włostowski et al.·Tetrahedron-asymmetry
Tetrahedron-asymmetry