Paper
Perfluorooctanoic acid (PFOA) exposure inhibits DNA methyltransferase activities and alters constitutive heterochromatin organization.
Published Apr 18, 2020 · Wenjie Liu, J. Irudayaraj
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Q1 SJR score
18
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
PFOA exposure leads to global DNA demethylation and alters heterochromatin organization, potentially increasing susceptibility to diseases like cancer.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Acute PFOA exposure promotes epigenomic alterations in mouse kidney tissues
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Citations
Prenatal Perfluoroalkyl Substance Exposure in Association with Global Histone Post-Translational Methylation in 2-Year-Old Children
Prenatal exposure to perfluoroalkyl substances (PFASs) is associated with global histone methylation changes in 2-year-old children.
2024·0citations·Wan-Ju Tsai et al.·Toxics
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Comparative steroidogenic effects of hexafluoropropylene oxide trimer acid (HFPO-TA) and perfluorooctanoic acid (PFOA): Regulation of histone modifications.
HFPO-TA exhibits stronger effects on steroidogenesis compared to PFOA, suggesting it is not a safer alternative for male reproductive toxicity.
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Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice: Insights into epigenetic mechanisms and pathway-specific responses.
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Effects of Perfluorooctanoic Acid on Endoplasmic Reticulum Stress and Lipid Metabolism-related Genes in Human Pancreatic Cells.
PFOA-induced pancreatic toxicity involves epigenetic mechanisms, disruption in glucose-lipid metabolism, and changes in endoplasmic reticulum stress-related genes.
2023·1citation·Mahmoud Abudayyak et al.·Environmental toxicology and pharmacology
Environmental toxicology and pharmacology
A machine learning approach to elucidating PFOS-induced alterations of repressive epigenetic markers with single-cell imaging
PFOS exposure in kidney cancer cells leads to distinct epigenetic changes, potentially contributing to toxicity development and disease progression.
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Environmental Advances