Paper

Structural, conformational, biochemical, and pharmacological study of some amides derived from 3,7-dimethyl-3,7-diazabicyclo [3.3.1] nonan-9-amine as potential 5-HT3 receptor antagonists

Published Dec 1, 1995 · M. J. Fernández, R. Huertas, E. Gálvez

Journal of Molecular Structure-theochem

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Abstract

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In Vitro Study

Study Snapshot

Compounds derived from 3,7-dimethyl-3,7-diazabicyclo [3.3.1] nonan-9-amine show potential as 5-HT3 receptor antagonists, with compound 4b showing significant results in the von Bezold-Jarish reflex at 25 mg Kg-1.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Structural, conformational, biochemical, and pharmacological study of some amides derived from 3,7-dimethyl-3,7-diazabicyclo [3.3.1] nonan-9-amine as potential 5-HT3 receptor antagonists

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