[The pharmacology of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt].

Paper

[The pharmacology of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt].

Published 1978 · A. Uspenskii

Farmakologiia i toksikologiia

UNKNOWN SJR score

0

Citations

0

Influential Citations

Semantic Scholar

Abstract

Sodium salt of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid inhibits exploratory behavior and induces hypothermia in mice. The compound enhances central effects of L-DOPA, such as: gross excitation in group, fighting behavior, anticataleptogenic action and hyperthermic effect. The L-DOPA central effects are mitigated by pyridoxal phosphate. The 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt abolishes the protective action of pyridoxal phosphate. In vitro this salt inhibits DOPA-decarboxylase. It is suggested that the compound under discussion is a competitive antagonist of L-DOPA, when the latter is involved in reactions with pyridoxal phosphate.

Study Snapshot

The sodium salt of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid inhibits exploratory behavior and induces hypothermia in mice, enhancing central effects of L-DOPA and acting as a competitive antagonist when involved in reactions with pyridoxal phosphate.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

[The pharmacology of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt].

References

Citations