Paper
Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery
Published Feb 1, 2007 · C. Taylor, T. Angelotti, E. Fauman
Epilepsy Research
Q2 SJR score
459
Citations
8
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Pregabalin reduces neuronal excitability and seizures by binding to the alpha2–delta subunit of voltage-gated calcium channels, potentially through reduced neurotransmitter release.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Pregabalin action at a model synapse: Binding to presynaptic calcium channel α2-δ subunit reduces neurotransmission in mice
Pregabalin reduces presynaptic neurotransmitter release without altering postsynaptic receptors or contraction coupling, making it a potential treatment for peripheral neuropathic pain and epilepsy.
2006·61citations·Indu Joshi et al.·European Journal of Pharmacology
European Journal of Pharmacology
The Calcium Channel α2δ-2 Subunit Partitions with CaV2.1 into Lipid Rafts in Cerebellum: Implications for Localization and Function
The calcium channel 2-2 subunit and CaV2.1 subunit are normally associated with cholesterol-rich microdomains, which influence their functionality in the cerebellum.
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The Journal of Neuroscience
Pregabalin Reduces the Release of Synaptic Vesicles from Cultured Hippocampal Neurons
Pregabalin slightly reduces neurotransmitter release from presynaptic sites in living hippocampal neurons, with effects most apparent before and early during electrical stimulation.
2006·117citations·Kristina D. Micheva et al.·Molecular Pharmacology
Molecular Pharmacology
Learning from stargazin: the mouse, the phenotype and the unexpected
Stargazin gene may play a role in epileptic phenotypes, but its function in VDCC regulation remains unclear.
2006·69citations·P. Osten et al.·Current Opinion in Neurobiology
Current Opinion in Neurobiology
Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation
Elevated neuronal calcium 21 contributes to specific pain states through enhanced VGCC activity in sensory neurons and hyperexcitability in dorsal horn neurons in response to peripheral stimulation.
2006·240citations·Chun-Ying Li et al.·Pain
Pain
Citations
Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety
Pregabalin is more effective and faster in alleviating neuropathic pain than gabapentin, improving patient-reported outcomes, reducing opioid consumption, and causing fewer adverse events.
2025·1citation·Victor Mayoral et al.·Frontiers in Pain Research
Frontiers in Pain Research
An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.
Serotonin toxicity is a life-threatening condition that can be prevented by regular medication adjustments and non-pharmacological treatment of chronic pain in older adults.
2024·0citations·Olga Abel et al.·Journal of pain & palliative care pharmacotherapy
Journal of pain & palliative care pharmacotherapy
The efficacy of topical 8% capsaicin patches for the treatment of postsurgical neuropathic pain: a systematic review.
Topical 8% capsaicin patches show potential in decreasing postsurgical neuropathic pain levels and area, but larger randomized-controlled trials are needed to confirm their effectiveness.
2024·0citations·Brandon Goodwin et al.·Pain management
Pain management
Pregabalin for Neuropathic Pain in Post-radiotherapy Head and Neck Cancer Patients: A Retrospective Study and Review of the Literature
Pregabalin may be a promising option for managing radiotherapy-related chronic neuropathic pain in head and neck cancer patients.
2024·0citations·Maria Kouri et al.·Cureus
Cureus
Epinephrine, Pregabalin, and Crizotinib as Three Medicines with Polish Implications over Three Last Centuries and in View of Three Different Drug Discovery Approaches
Polish researchers have significantly contributed to the discovery and advancement of epinephrine, pregabalin, and crizotinib, highlighting Poland's significant role in global pharmaceutical innovations and medical research.
2024·0citations·Piotr Kawczak et al.·Biomedicines
Biomedicines
Effect of oral administration of pregabalin on physiological and echocardiographic variables in healthy cats
A single dose of oral pregabalin can cause mild to moderate sedation in healthy cats, with more frequent hypotension observed in the 5 mg/kg and 10 mg/kg groups.
2024·0citations·Meng Li et al.·Journal of Feline Medicine and Surgery
Journal of Feline Medicine and Surgery
Gabapentin treatment for challenging behaviors in autism spectrum disorder and coexisting intellectual disability: a case report
Gabapentin treatment improves challenging behaviors and aggressions in an adult with autism spectrum disorder and severe intellectual disability, without causing side effects.
2024·0citations·S. Marini et al.·Advances in Mental Health and Intellectual Disabilities
Advances in Mental Health and Intellectual Disabilities