Paper
The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations
Published Jun 1, 2017 · S. Petrosino, V. Di Marzo
British Journal of Pharmacology
272
Citations
21
Influential Citations
Abstract
Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this compound is naturally produced in many plant and animal food sources, as well as in cells and tissues of mammals, and endowed with important neuroprotective, anti‐inflammatory and analgesic actions. Several efforts have been made to identify the molecular mechanism of action of PEA and explain its multiple effects both in the central and the peripheral nervous system. Here, we provide an overview of the pharmacology, efficacy and safety of PEA in neurodegenerative disorders, pain perception and inflammatory diseases. The current knowledge of new formulations of PEA with smaller particle size (i.e. micronized and ultra‐micronized) when given alone or in combination with antioxidant flavonoids (i.e. luteolin) and stilbenes (i.e. polydatin) is also reviewed.
Palmitoylethanolamide (PEA) shows potential as a nutraceutical for neuroprotection, anti-inflammatory, and analgesic effects in neurodegenerative disorders, pain perception, and inflammatory diseases.
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