Paper
PHENMETRAZINE hydrochloride.
Published 1957 · R. Feldman, C. Edmond, Alberton
Journal of the American Medical Association
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Abstract
A NEW ANORETIC AGENT, phenmetrazine hydrochloride (Preludin®*), has had extensive use in Europe, especially in Germany, over the past two years with encouraging results.2'4'7 A number of clinical reports have recently appeared in this country as well.8 5'6 Phenmetrazine has the chemical formula of 2phenyl-3 methyl-tetrahydro-1, 4 oxazine hydrochloride and is a white, odorless, crystalline powder with a bitter taste. The toxicity of the drug, as judged both by the LD50 in mice and the amount needed for central nervous system excitement, is approximately one-fifth that of amphetamine.8 Phenmetrazine in the same dose as epinephrine has a relatively weak effect on blood pressure; in dogs it brings about approximately one one-thousandth as much rise in blood pressure.8 The mode of the anoretic action of this drug has not yet been determined. Results of a clinical evaluation of its effect on obesity are presented in this communication.
Phenmetrazine hydrochloride (Preludin®) shows promising results in obesity treatment, with a low toxicity and weak effect on blood pressure.
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