Paper

Phenoxide leaving group SNAr strategy for the facile preparation of 7-amino-3-aryl pyrazolo[1,5-a]pyrimidines from a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate

Published Oct 28, 2015 · J. Catalano, V. Gaitonde, M. Beesu

Tetrahedron Letters

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Abstract

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Study Snapshot

This study presents a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate that allows for direct sequential functionalization of the 3-position and 7-position of a pyrazolo[1,5-a]pyrimidine scaffold, offering an improvement over prior methods.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Phenoxide leaving group SNAr strategy for the facile preparation of 7-amino-3-aryl pyrazolo[1,5-a]pyrimidines from a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate

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