Paper

Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.

Published Sep 1, 2019 · Helloana Azevedo-Barbosa, Guilherme A. Ferreira-Silva, C. Silva

Toxicology in vitro : an international journal published in association with BIBRA

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Abstract

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In Vitro Study

Study Snapshot

Phenylpropanoid-based sulfonamide 4b shows promising antitumor activity by reducing cyclin D1 and cyclin E expression and inducing cell cycle arrest at G1/S transition in estrogen positive MCF-7 breast cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.

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