A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

This study developed a simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines under mild conditions, offering a promising route to synthetically useful and biologically active heterocycles.

Paper

A phosphine-mediated construction of 1,4-oxazepines and 1,3-oxazines.

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