Piperidine Catalyzed Four–component Strategy for the Facile Access of Polyfunctionalized 1,4‐Dihydropyridines at Ambient Conditions

doi:10.1002/SLCT.201601358

Paper

Piperidine Catalyzed Four–component Strategy for the Facile Access of Polyfunctionalized 1,4‐Dihydropyridines at Ambient Conditions

Published Oct 1, 2016 · R. Ramesh, R. Madhesh, J. Małecki

12

Citations

0

Influential Citations

Full text

Abstract

A highly efficient and practical method has been disclosed for the convenient access of structurally diverse 1,4-dihydropyridines via one-pot, four-component reactions of aryl aldehydes, different C−H activated acidic compounds bearing nitrile moiety, dimethyl acetylenedicarboxylate and aromatic/aliphatic amines using piperidine as an effective organo-base catalyst in ethanol at ambient conditions. This domino synthetic strategy proceeded very smoothly and provided immense advantages, including facile operational procedure, excellent product yields, shorter reaction time and applicability to wide range of substrates. This protocol furnishes an alternate route to construct a library of potent DHPs under the shade of green chemistry principle.

Study Snapshot

This study presents a one-pot, four-component strategy for facile access to diverse 1,4-dihydropyridines using piperidine as an organo-base catalyst in ethanol under ambient conditions, offering a green chemistry alternative for building a library of potent DHPs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Piperidine Catalyzed Four–component Strategy for the Facile Access of Polyfunctionalized 1,4‐Dihydropyridines at Ambient Conditions

References

Citations