Paper
Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus
Published Feb 1, 2006 · I. Khan, Zahid Mehmood Mirza, Ashwani Kumar
Antimicrobial Agents and Chemotherapy
Q1 SJR score
210
Citations
10
Influential Citations
Abstract
ABSTRACT Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.
In Vitro Study
Highly CitedStudy Snapshot
Piperine, a phytochemical, significantly reduces the MIC and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant strains.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Citations
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